We recently reported that peroxisome proliferator-activated receptor α (PPARα) agonist, fenofibrate, prevents iron-induced oxidative stress and β-catenin signaling by chelating the iron. Aberrant Wnt/β-catenin signaling is a hallmark of several hepatic pathologies. However, our knowledge on how iron contributes to the liver injury is limited. Iron accumulation is frequently associated with chronic liver diseases.
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